Circadian Entrainment Triggers Maturation of Human In Vitro Islets
Epigenomic studies reveal mechanisms driving differentiation of human stem cells into pancreatic islets and uncover a role for circadian rhythms in their functional maturation. Circadian-clock-entrained islets gain metabolic oscillations and stable chromatin changes that trigger cyclic insulin responses with a raised glucose threshold and function within days of transplant.
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High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia
Vaidyanathan et al. use Cas9 and AAV to correct the CF causing ΔF508 mutation in >30% of alleles in airway basal stem cells from CF patients and embed corrected cells on a scaffold for engraftment. This method restores physiologic CFTR function and provides an ex vivo strategy to treat cystic fibrosis.
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Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer
Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.
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Immune outposts inside kidney tumors predict post-surgery outcomes (Wed, 11 Dec 2019)
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New bone healing mechanism has potential therapeutic applications (Mon, 09 Dec 2019)
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Scientists push bioprinting capability forward (Wed, 04 Dec 2019)
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Transition to exhaustion: Clues for cancer immunotherapy (Tue, 03 Dec 2019)
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How stem cells decide their identity (Tue, 03 Dec 2019)
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New technique visually depicts how cancer cells grow and spread in colon tissue (Mon, 02 Dec 2019)
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Stem cell therapy helps broken hearts heal in unexpected way (Wed, 27 Nov 2019)
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Silencing retroviruses to awaken cell potential (Wed, 27 Nov 2019)
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Tendon stem cells could revolutionize injury recovery (Tue, 26 Nov 2019)
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Cerebral organoid model provides clues about how to prevent virus-induced brain cell death (Tue, 26 Nov 2019)
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Intestinal stem cell genes may link dietary fat and colon cancer (Mon, 25 Nov 2019)
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Complex organ models grown in the lab (Tue, 19 Nov 2019)
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RNA regulation is crucial for embryonic stem cell differentiation (Tue, 19 Nov 2019)
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Discovery: New biomarker for cancer stem cells (Wed, 13 Nov 2019)
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Protein could offer therapeutic target for pancreatic cancer (Tue, 12 Nov 2019)
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