Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration
Yu et al. show that Hoxc gene expression in mesenchymal niches controls epithelial stem cell activation via Wnt signaling. Hoxc expression patterns vary at the tissue level, suggesting that the regenerative landscape of the skin is governed by mesenchymal niche plasticity.
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Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency
Optimized partial depletion of Mbd3 had been implicated in deterministic reprogramming. Hanna and colleagues now dissect the subcomplex within Mbd3/NuRD that underlies this outcome. Gatad2a is identified as a flexible component that can be entirely ablated without compromising somatic cell proliferation and yet still similarly yields deterministic mouse iPSC formation.
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Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration
Himburg et al. demonstrate dichotomous regulation of blood stem cell maintenance and regeneration by BM stromal cells and ECs. Utilizing conditional genetic models, the authors show that blood stem cell maintenance requires PTN secretion by BM stromal cells, whereas blood stem cell regeneration requires complementary PTN production by BMECs.
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Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration
Tomic et al. report that multisite phosphorylation of ATOH1 regulates the contribution of secretory progenitors to stem cell self-renewal in the small intestine and colon. With damage, the enhanced role of Atoh1+ progenitors in mediating tissue repair is ablated in mice expressing phosphomutant ATOH1 and overall tissue regeneration is impaired.
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Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification
Sadahiro et al. show that Tbx6 is critical for mesoderm induction and subsequent lineage diversification from pluripotent stem cells (PSCs). Transient Tbx6 expression induced nascent mesoderm and cardiovascular lineages from mouse and human PSCs, whereas prolonged Tbx6 expression suppressed cardiac differentiation and induced somite lineages, including skeletal muscle and chondrocytes.
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Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications
Matoba and Zhang discuss recent advances in somatic cell nuclear transfer technology, particularly new methods to overcome epigenetic barriers, and highlight the potential applications of this cloning technology for both reproductive efforts and therapy.
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Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development
Matoba et al. show that mouse cloning efficiency can be significantly improved by simultaneously overcoming two reprogramming barriers, Xist and H3K9me3, although efficiency is still low in comparison with IVF. Comprehensive analyses showed that SCNT embryos can have complete loss of H3K27me3 imprinting, likely explaining this low efficiency.
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Modulating Cell Fate as a Therapeutic Strategy
In this Perspective, Lin et al. highlight examples of plasticity during normal regeneration and in aberrant situations in a variety of tissues. The authors also discuss the merits of enhancing endogenous plasticity to promote regeneration and reversing pathologic plasticity as potential therapeutic strategies.
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This matrix delivers healing stem cells to injured elderly muscles (Wed, 15 Aug 2018)
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Magnetic gene in fish may someday help those with epilepsy, Parkinson's (Tue, 14 Aug 2018)
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Single transplantation of therapeutic macrophages improves rare lung disease in mice (Thu, 09 Aug 2018)
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Tbx6 revealed as crucial to heart and skeleton formation from stem cells (Thu, 09 Aug 2018)
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Anticancer drugs delivered by a new drug delivery system reduce tumor size (Wed, 08 Aug 2018)
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Back to the future: breast cancer reprises pathways found in fetal cells (Tue, 07 Aug 2018)
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Double time limit for embryo research, say ethics experts (Tue, 07 Aug 2018)
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Created line of spinal cord neural stem cells shows diverse promise (Mon, 06 Aug 2018)
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New research opens door to expanding stem cells available for transplants (Fri, 03 Aug 2018)
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New stem cell model can be used to test treatments for a rare nervous system disorder (Thu, 02 Aug 2018)
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Stem cell research for cystic fibrosis leaps forward (Thu, 02 Aug 2018)
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Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice (Wed, 01 Aug 2018)
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Leopard geckos can make new brain cells (Sat, 28 Jul 2018)
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Can scientists leverage mysterious mossy cells for brain disease treatments? (Thu, 26 Jul 2018)
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Researchers discover system that could reduce neurodegeneration in Huntington's disease (Thu, 26 Jul 2018)
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