Engineering Ethics and Self-Organizing Models of Human Development: Opportunities and Challenges
Incorporating engineering ethics early during the planning stages of organoid and gastruloid research may help prevent future confusion about the moral status of complex models of human development. However, the intrinsic self-organizing behavior of organoids and gastruloids may pose a slight challenge to this novel ethical approach.
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Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming
Miura and Suzuki describe direct conversion of mouse fibroblasts to cells resembling fetal intestine-derived progenitor cells that can give rise to intestinal stem cell organoids and reconstitute injured colonic tissues after transplantation. They also show that a similar approach can work to make human induced intestinal progenitor cells.
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Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells
Toda et al. demonstrate that the nucleoporin Nup153 interacts and cooperates with Sox2 to regulate the cellular state of neural progenitor cells. Nup153 binds both the 5′ and 3′ ends of genes, and the direction of gene regulation by Nup153 varies with the binding position of Nup153.
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Production of key diabetes cells can be improved (Thu, 21 Sep 2017)
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Genome editing reveals role of gene important for human embryo development (Wed, 20 Sep 2017)
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Getting to the heart of the matter: Nanogels for heart attack patients (Wed, 20 Sep 2017)
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Cell model of the brain provides new knowledge on developmental disease (Tue, 19 Sep 2017)
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'Language of stem cells' discovered (Tue, 19 Sep 2017)
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New inhibitor brings new hope for aggressive triple receptor-negative breast cancer (Thu, 14 Sep 2017)
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In mice, calorie restriction reduces fat but increases fur (Tue, 12 Sep 2017)
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Outside-in reprogramming: Antibody study suggests a better way to make stem cells (Mon, 11 Sep 2017)
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Human skin cells transformed directly into motor neurons (Thu, 07 Sep 2017)
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Shortened telomeres linked to dysfunction in Duchenne muscular dystrophy, researchers find (Thu, 07 Sep 2017)
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Improved stem cell transplantation therapies? (Thu, 07 Sep 2017)
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New model for hard-to-study form of blindness paves way for future research (Wed, 06 Sep 2017)
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The protein TAZ sends 'mixed signals' to stem cells (Wed, 06 Sep 2017)
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Zika virus kills brain cancer stem cells (Tue, 05 Sep 2017)
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Zika virus could be used to treat brain cancer patients, study suggests (Tue, 05 Sep 2017)
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