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Reverse Aging with Stem Cell Research

Stem Cell News

Injury Activates Transient Olfactory Stem Cell States with Diverse Lineage Capacities
Gadye et al. use multiple single-cell techniques to identify the cell state transitions underlying the stem cell self-renewal and differentiation during injury-induced regeneration of the olfactory epithelium. Olfactory stem cells shift en masse to a transient cell state unique to regeneration in which diverse fates are specified.
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Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
Ruetz et al. show that constitutively active SMAD2/3 has a surprising ability to boost the efficiency of cell reprogramming both to iPSCs and across lineages and may therefore be a general factor that can enhance transcription-factor-mediated reprogramming in a variety of contexts.
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Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency
Lin et al. demonstrate that Ascl1+ and Neurog1+ neuronal progenitors can acquire cell fate plasticity after injury using genetic lineage trace and transplantation assays. Injury-induced multipotency occurs through a developmentally reminiscent endogenous upregulation of Sox2, KLF4, and Pax6, and dedifferentiation efficiency can be enhanced by Ezh2 inhibition.
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Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
Taguchi and Nishinakamura define signals that specifically induce ureteric bud and nephron progenitor lineages from PSCs. Co-culturing these progenitors can generate organoids that mimic organotypic architecture of the embryonic kidney with nephrons interconnected by branched epithelium, showing that higher-order organogenesis can be recapitulated in PSC-derived organoids.
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Engineering Ethics and Self-Organizing Models of Human Development: Opportunities and Challenges
Incorporating engineering ethics early during the planning stages of organoid and gastruloid research may help prevent future confusion about the moral status of complex models of human development. However, the intrinsic self-organizing behavior of organoids and gastruloids may pose a slight challenge to this novel ethical approach.
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Stem Cell News: Science Daily

HLF-gene controls generation of our long-term immune system (Wed, 22 Nov 2017)
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Key signaling protein for muscle growth (Mon, 20 Nov 2017)
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Brain cell advance brings fresh hope for Creutzfeldt-Jakob disease therapies (Mon, 20 Nov 2017)
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Deletion of a stem cell factor promotes traumatic brain injury recovery in mice (Fri, 17 Nov 2017)
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Investigating patterns of degeneration in Alzheimer's disease (Fri, 17 Nov 2017)
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Brain astrocytes linked to Alzheimer's disease (Fri, 17 Nov 2017)
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Paraplegic rats walk and regain feeling after stem cell treatment (Thu, 16 Nov 2017)
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Cell-based therapy for type 1 diabetes? (Wed, 15 Nov 2017)
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Key to unlock blocked differentiation in microRNA-deficient embryonic stem cells (Wed, 15 Nov 2017)
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Why testicular cancer is so responsive to chemo (Tue, 14 Nov 2017)
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Effective therapy against glioblastoma by attacking telomeres (Mon, 13 Nov 2017)
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Innovative genetic, cellular techniques help identify multiple disease targets (Mon, 13 Nov 2017)
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Improving the neuron factory: New modulator of stem cell identity found (Mon, 13 Nov 2017)
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Understanding the Berlin patient's unexpected cure of HIV (Fri, 10 Nov 2017)
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Induced pluripotent stem cells show astrocyte-neuron impact on brain pathology in autism (Thu, 09 Nov 2017)
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